What is causes kidney failure?

What causes kidney failure is? Healthy people have a discomfort medication is normal, it will not lead to kidney problems, but the patient's long-term medication easily lead to acute renal failure due to drugs. What causes kidney failure, we look at the related presentations.
1, renal ischemia
Is because of improper treatment of some diseases, which leads to renal ischemia caused severe renal ischemia such as severe trauma, extensive burns, major surgery, massive blood loss, obstetric hemorrhage, severe infections, sepsis, dehydration and electrolyte imbalance, particularly is combined with shock who are easily lead to acute tubular necrosis. Therefore, in the course of treatment, for this reason should pay more attention.
2, toxic substances

Because some of the kidneys caused by toxic substances, such as sulfa drugs, carbon tetrachloride, amalgam, bismuth dichloride, sulfonamides (dichlorphenamide); polymyxin antibiotic, vancomycin, kanamycin neomycin, gentamicin, neomycin Pioneer Ⅰ, vanguard ADM Ⅱ, neomycin, amphotericin B, and iodine contrast agent, methoxyflurane anesthetics; biological toxins such as snake venom, bee venom, fish mushroom cantharidin (Cantharidin), etc., can under certain conditions cause acute tubular necrosis. So be sure to avoid contact with these usually have kidney toxic substances.